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Steroid medicines are man-made but are similar to these natural hormones. Steroid medicines used to treat disease are also called corticosteroids. Oral steroids are used to treat a large number of conditions, usually by reducing inflammation or the effect of the persons immune system. Some examples include: inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), autoimmune diseases (e.g., systemic lupus erythematosus (SLE), autoimmune hepatitis), relapses of multiple sclerosis, joint and Muscle diseases (e.g., rheumatoid arthritis, polymyalgia rheumatica), allergies, asthma, chronic obstructive pulmonary disease (COPD), croup. Oral steroids are also used to treat the effects of some cancers or to treat conditions in which a person is not making enough of their own natural steroids (for example, in Addison's disease, congenital adrenal hyperplasia and hypopituitarism).

Steroids are a man-made version of hormones normally produced by the adrenal glands which are 2 small glands found above the kidneys. Steroids reduce redness and swelling (inflammation). This can help with inflammatory conditions such as asthma and eczema. Steroids also reduce the activity of the immune system, which is the body's natural defence against illness and infection. This can help treat autoimmune conditions, such as rheumatoid arthritis or lupus, which are caused by the immune system mistakenly attacking the body.

*Anti-inflammation: Steroids are primarily anti-inflammatory. They inhibit inflammatory pathways and minimize the production of inflammatory chemical mediators. Steroids effectively reduce inflammation and further tissue damage.
An active immune system is vital as your natural defense against illness and infection. But in cases of autoimmune conditions, it can be a cause of disease. Autoimmune diseases occur when your immune system mistakenly attacks your healthy cells. The immune-suppressive effect of steroids is one of the main mechanisms by which it helps treat immune-mediated diseases, like psoriasis, rheumatoid arthritis, and others.

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Auto-Immune Diseases:

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After an organ transplant, your immune system may see the transplanted organ as a harmful, foreign body that it needs to attack. The suppression of your immune system by steroids decreases the risk of organ rejection. These steroids are called immunosuppressive or anti-rejection medicines.

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COVID-19: Patients with severe COVID-19 may develop a systemic inflammatory response that results in lung injury and organ failure. The anti-inflammatory and immunosuppressive properties of steroids can prevent adverse effects in critically ill patients with COVID-19.

Corticosteroids, also known as steroids, are life-saving drugs prescribed by medical practitioners for the effective management of potentially life-threatening illnesses like asthma, autoimmunity and cancer. Although it is very effective, steroids come with a host of undesirable side effects such as osteoporosis, hyperglycaemia, Cushing s syndrome, depression and immunosuppression which can alter the quality of the patient s life. We list down six important lifestyle tips to mitigate the side effects of steroid treatment.

Corticosteroid usage causes sodium retention in the body, which in turn causes fluid retention and weight gain. Avoiding salt in your diet is one way to address this problem effectively. Apart from salt, stay away from processed food, soy sauces and other store-bought condiments which may be high in sodium. Find out how you can beat salt cravings.

Corticosteroids are anti-inflammatory medicines which hamper immune functions. If you are on these medications, your body is immune-compromised or ill-equipped to deal with some of the infections that may come your way. Following proper hygiene, keeping your nose and mouth covered, and avoiding close contact with infected people may help you stave off infection till the time you are on steroids.

One of the commonest side effects of steroids is the increase of glucose levels in the blood. If you have existing diabetes problems, your physician should be notified. Monitoring your blood sugar levels during the treatment is also necessary. Staying away from carb-laden food and sugary beverages will also help.

Peptic ulcer disease, tuberculosis, active infections and psychosis are all contraindications to the prescribing of oral corticosteroids. Patients need to be screened for symptoms of psychosis, which may include a history of depression, delirium, hallucination, confusion or distress. Steroids are also contraindicated during pregnancy. Children should be prescribed steroids with caution due to inhibition of growth with steroid medications. Corticosteroids may also cause interactions with other medications the patient may be taking, and it will be important to review their current medications prior to prescribing. Caution is advised with nonsteroidal anti-inflammatory agents or anticoagulants, which may need prophylaxis to avoid gastroduodenal toxicity. While not a contraindication, patients with comorbidities - including diabetes mellitus, poorly controlled hypertension, significant cardiovascular issues (i.e., atherosclerotic disease and arrhythmias), cataracts, glaucoma, peptic ulcer disease and osteoporosis should be prescribed steroids judiciously. It is wise to consult with the patient's primary care provider or internist when considering oral steroid therapy for these individuals.

With long-term use, some of the more common side effects of steroids include changes in appearance, such as acne, development of a round or moon-shaped face and an increased appetite leading to weight gain. Steroids may also cause a redistribution of fat, leading to a swollen face and abdomen, but thin arms and legs. In some cases, the skin becomes more fragile, which leads to easy bruising. These take weeks to begin appearing. The following are possible side effects of taking too much oral steroids:

Other side effects that may be caused by the long-term use of steroids include cataracts, muscle weakness, avascular necrosis of bone and osteoporosis. These usually do not occur with less than four weeks of treatment.

Steroids reduce calcium absorption through the gastrointestinal tract that may result in osteoporosis, or thinning of the bones. Osteoporosis can lead to bone fractures, especially compression fractures of the vertebrae, causing severe back pain. Calcium, at least 1500 mg of the calcium carbonate form or equivalent, should be taken. There are new medications (Fosamax in particular) that also may help to prevent osteoporosis.

A: This word has different meanings. Steroids are chemicals, usually hormones, naturally produced by the body. They help your organs, tissues, and cells function. You need a healthy balance of them to grow and even have babies. "Steroids" can also refer to man-made drugs. The two main types are corticosteroids and anabolic androgenic steroids (or simply anabolic steroids).

A: Oral steroids are usually tapered over 3-6 weeks. Let's say, for example, you're taking prednisolone 40 mg. You will be instructed to reduce your dose by 10 mg every 3 days until your dose is 10 mg per day. Afterwards, you should reduce your dose to 5 mg for 5 more days and then stop. There's usually no standard way to taper down steroids, and each doctor will provide a cessation plan depending on how long you've been taking steroids, their type, and other factors.

A: Steroids are anti-inflammatory drugs and are prescribed for a range of conditions associated with inflammatory and immune diseases. Your doctor may prescribe steroids for allergies, asthma, eczema, lung disorders, muscular and joint pains, and autoimmune disease.

A: Steroids reduce inflammation and suppress the activity of your immune system. They may be prescribed to relieve various conditions, ranging from allergies to autoimmune disease and even COVID-19.

A: Steroid pills and syrups are very effective at reducing swelling and mucus production in the airways. They also help other quick-relief medication work better. They are often necessary for treating more severe episodes of lung disease.

A: Many people with chronic lung disease periodically require a short-term burst of steroid pills or syrups to decrease the severity of acute attacks and prevent an emergency room visit or hospitalization. A burst may last two to seven days and may not require a gradually decreasing dosage. For others, a burst may need to continue for several weeks with a gradually decreasing dosage. You may experience a few mild side effects such as increased appetite, fluid retention, moodiness and stomach upset. These side effects are temporary and typically disappear after the medicine is stopped.

A: But over 30 days is generally considered long-term steroid use. Most often, oral corticosteroids are prescribed for roughly 1 to 2 weeks - and only for very severe symptoms. But for certain chronic health conditions, such as rheumatoid arthritis, corticosteroids may be necessary for months or even years.

A: Rapid mood swings in steroid users likely occur because of hormone spikes and dangerously high Testosterone levels. Evidence points to hormone balance being the key to steady moods. While Testosterone may encourage aggression and other social-enhancing behaviors in men, hormones like cortisol and serotonin reduce these effects. Men with low Testosterone may also be more aggressive and irritable due to hormone imbalance. It's important to work with a knowledgeable provider who can create an individualized TRT plan that helps you find balance.

A: *Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack, and also any other printed information you have been given by your doctor or pharmacist. The manufacturer's leaflet will give you more information about prednisolone and a full list of side-effects which you may experience from taking it.

*Most prednisolone tablets should be taken with food. The food helps to protect the lining of your stomach from any irritation. If you have been given enteric-coated tablets (these are red or brown), these tablets are specially coated to help protect your stomach and can be taken either before or after food.
*Enteric-coated (red or brown) tablets should be swallowed whole - do not chew or crush them. Also, it is important that you do not take any indigestion remedies (such as an antacid) during the two hours before you take a dose or during the two hours after you have taken a dose. This is because they interfere with the special coating on your tablets.

A: Along with its useful effects, prednisolone can cause unwanted side-effects which your doctor will discuss with you. The benefits of taking prednisolone usually outweigh the side-effects, although unwanted effects can sometimes be troublesome. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Although not everyone experiences side-effects, and some will improve as your body adjusts to the new medicine, you should speak with your doctor or pharmacist if you become concerned about any effects.

A: Stopping your steroid medication is something that should be thoroughly discussed with your doctor. Your doctor will likely tell you that you cannot stop taking steroids suddenly. Sudden cessation of steroid therapy may interfere with the normal hormonal balance in your body. When you're on long-term oral or intravenous steroid therapy, your adrenal glands will not produce much cortisol themselves, since your blood cortisol levels are artificially high from steroid therapy. So, the adrenal glands become lazy over time. They become used to not producing much cortisol. This is why doctors taper down steroids at the end of therapy. Tapering means that your dose is slowly reduced over a few days before you can stop therapy completely. This gives your adrenal glands time to re-adjust and slowly increase endogenous steroid production back to the normal levels. During the tapering-off process, your doctor will monitor you for potential adverse effects.

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